HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Fluoroaniline → [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Fluoroaniline | HCID 9731 | — |
| Edukt | (4-Bromo-2-chloro-phenyl)-(2-methyl-5-nitro-phenyl)-methanone | HCID 11494123 | — |
| Edukt | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 11618303 | — |
| Produkt | [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone | HCID 68419037 | — |
Reaktionsschritte
The reaction was carried out similarly as described in the preparation of compound 403, using compound 402 (22.6 mmol) and 4-fluoroaniline (24.8 mmol) except the time for the reaction was 16 h. The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:5 as the eluent to afford the title compound as yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08293772B2 |
| Quelldatensatz | uspto-grants-2012_10 |
| ORD ID | ord-66bc3954aef9491da07535f74576e44c |
| Quellennotiz | uspto-grants-2012_10 |