[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone → [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

HRID 2067225Notes

Reaction equation

HRID 2067225 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:20]=1[CH3:26])=[O:18].NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(F)=CC=3)=CC=2Cl)=O)C=1>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:20]=1[CH3:26])=[O:18]

Participants

3

Reactant 2

HCID 67314444[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanoneHCID 68418042(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-phenylamino)-phenyl]-methanone

Product 1

HCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 405, using compound 429 (8.46 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 2:8 followed by 3:7 as the eluent to afford the title compound as solid.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-4621356e2f864caf9e7fbce6c832f793
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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