HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone → [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone | HCID 67314444 | — |
| Reactant | (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-phenylamino)-phenyl]-methanone | HCID 68418042 | — |
| Product | [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone | HCID 68421852 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 405, using compound 429 (8.46 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 2:8 followed by 3:7 as the eluent to afford the title compound as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4621356e2f864caf9e7fbce6c832f793 |
| Source note | uspto-grants-2012_10 |