Trimethylsilylacetylene → HCID 68418431, compound

HRID 2067226Notes

Reaction equation

HRID 2067226 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(I)C=CC=1C)=O.C([Si](C)(C)C)#C>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:28])([CH3:30])[CH3:29])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

Participants

4

Reactant 3

HCID 66111TrimethylsilylacetyleneHCID 67314552HCID 67314552, compoundHCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

Product 1

HCID 68418431HCID 68418431, compound

Procedure

The reaction was carried out similarly as described in the preparation of compound 406, using compound 430 (7.17 mmol) and ethynyltrimethylsilane (7.17 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:8 as the eluent to afford the title compound as yellow solid.

Workup

  1. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-16cd4c58670c4f8ba427ad94984154f5
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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