反应详情

The reaction was carried out similarly as described in the preparation of compound 116, using compound 434 (0.125 mmol) and but-3-yn-2-one (0.125 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 0:100 to 50:50 as the eluent to afford the title compound.

1. customThe crude product was purified by continuous gradient flash chromatography