HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyn-2-one → 1-(1-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-1H-[1,2,3]triazol-4-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyn-2-one | HCID 15018 | — |
| Reactant | (5-Azido-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone | HCID 86605529 | — |
| Product | 1-(1-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-1H-[1,2,3]triazol-4-yl)-ethanone | HCID 11547234 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 116, using compound 434 (0.125 mmol) and but-3-yn-2-one (0.125 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 0:100 to 50:50 as the eluent to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-91a913085a3c41c9882523f9bdf1b49d |
| Source note | uspto-grants-2012_10 |