反应详情

温度

0 °C

A solution of compound 128 (250 mg, 0.53 mmol) in dry pyridine (2.0 mL) was flushed with argon and cooled to 0° C. 4-Methyl-benzenesulfonyl chloride (102 mg, 0.53 mmol) was added and the reaction was allowed to come to RT overnight under stirring. The reaction mixture was poured into a mixture of EtOAc/water. The organic phase was washed with water, brine, filtered and concentrated in vacuo to give the crude product. The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 25:75 to 50:50 as the eluent to afford the title compound.

1. washThe organic phase was washed with water, brine
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. customto give the crude product
5. customThe crude product was purified by continuous gradient flash chromatography