(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone

HRID 2067250Notes

Reaction equation

HRID 2067250 reaction equation
NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1.[Cl:29][C:30]1[CH:35]=[C:34]([NH:36][C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:38]=2[CH3:44])[CH:33]=[CH:32][C:31]=1[C:45]([C:47]1[CH:52]=[C:51]([N+:53]([O-])=O)[CH:50]=[CH:49][C:48]=1[CH3:56])=[O:46]>>[NH2:53][C:51]1[CH:50]=[CH:49][C:48]([CH3:56])=[C:47]([C:45]([C:31]2[CH:32]=[CH:33][C:34]([NH:36][C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:38]=3[CH3:44])=[CH:35][C:30]=2[Cl:29])=[O:46])[CH:52]=1

Participants

3

Reactant 2

HCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanoneHCID 68419909[2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone

Product 1

HCID 68418968(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 415, using compound 437 (0.41 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-2338fa786c1a42d2b243637b43ce3c03
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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