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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2067250Generated: November 2, 2026

(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone

https://huagongshe.com/reaction/2067250

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanoneHCID 68419668—
Reactant[2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanoneHCID 68419909—
Product(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanoneHCID 68418968—

Reaction Steps

The reaction was carried out similarly as described in the preparation of compound 415, using compound 437 (0.41 mmol). The crude product was used without any further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08293772B2
Source datasetuspto-grants-2012_10
ORD IDord-2338fa786c1a42d2b243637b43ce3c03
Source noteuspto-grants-2012_10