(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone → (5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone

HRID 2067251Notes

Reaction equation

HRID 2067251 reaction equation
[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:30])=[C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]3[CH:24]=[CH:23]C(C(F)(F)F)=[CH:21][CH:20]=3)=[CH:14][C:13]=2[Cl:29])=[O:11])[CH:9]=1)=[N+:2]=[N-:3].NC1C=CC(C)=C(C(C2C=CC(NC3C=C[C:50]([F:53])=[CH:49]C=3C)=CC=2Cl)=O)C=1>>[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:30])=[C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]3[CH:20]=[CH:21][C:50]([F:53])=[CH:49][C:24]=3[CH3:23])=[CH:14][C:13]=2[Cl:29])=[O:11])[CH:9]=1)=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 68418968(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanoneHCID 86605524(5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 86605531(5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 416, using compound 438 (0.29 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-ee2616a6216a482f93ca6b70e34dcb90
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

Loading…