反应详情

The reaction was carried out similarly as described in the preparation of compound 116, using compound 439 (0.29 mmol) and but-3-yn-1-ol (0.40 mmol). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100 to 5:95 as the eluent to afford the title compound.

1. customThe crude product was purified by continuous gradient flash chromatography