HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Butyn-1-OL → [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-{5-[4-(2-hydroxy-ethyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Butyn-1-OL | HCID 13566 | — |
| Reactant | (5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-methanone | HCID 86605531 | — |
| Product | [2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-{5-[4-(2-hydroxy-ethyl)-[1,2,3]triazol-1-yl]-2-methyl-phenyl}-methanone | HCID 11669891 | — |
Reaction Steps
The reaction was carried out similarly as described in the preparation of compound 116, using compound 439 (0.29 mmol) and but-3-yn-1-ol (0.40 mmol). The crude product was purified by continuous gradient flash chromatography using MeOH/DCM 0:100 to 5:95 as the eluent to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d207722a98874e4098e9d740c1c3ca3e |
| Source note | uspto-grants-2012_10 |