Dichloromethane → 1,1-Dimethylethyl (2-{[8-(2,6-difluorophenyl)-4-(2-methyl-5-{[(2-phenylethyl)amino]carbonyl}phenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}ethyl)methylcarbamate
Reaction equation
[CH3:53][CH2:54][N:55]([CH2:56][CH3:57])[CH2:58][CH3:59].[Cl:60][CH2:61][Cl:62].[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:40])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([S:37]([CH3:38])=[O:39])[n:17][c:18]3-[c:19]2[cH:20][c:21]([C:22](=[O:23])[NH:24][CH2:25][CH2:26][c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[cH:33][cH:34][c:35]2[CH3:36])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[NH2:41][CH2:42][CH2:43][N:44]([C:45]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:51])[CH3:52]>>[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:40])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([NH:41][CH2:42][CH2:43][N:44]([C:45]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:51])[CH3:52])[n:17][c:18]3-[c:19]2[cH:20][c:21]([C:22](=[O:23])[NH:24][CH2:25][CH2:26][c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[cH:33][cH:34][c:35]2[CH3:36])[c:4]([F:8])[cH:5][cH:6][cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-99bad658641d4263b8421bd96f171744
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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