Benzyl Bromide → HCID 58031623, compound

HRID 2067358Notes

Reaction equation

C(Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4]C=1.ICCCCC.[CH3:15][C:16]1[N:17]=[C:18]([N:26]2[CH2:30][CH2:29][NH:28][C:27]2=[O:31])[S:19][C:20]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH3:15][C:16]1[N:17]=[C:18]([N:26]2[CH2:30][CH2:29][N:28]([CH2:4][CH2:5][CH2:6][CH2:7][CH3:2])[C:27]2=[O:31])[S:19][C:20]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22]

Participants

Reactant 3

HCID 7498Benzyl Bromide

HCID 123351-Iodopentane

HCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 58031623HCID 58031623, compoundYield 69%

Procedure

Following the procedure as described in Example 5, making variations to replace benzyl bromide with 1-iodopentane to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 69% yield: 1H NMR (300 MHz, CDCl3) δ 4.23 (q, J=7.2 Hz, 2H), 4.11-3.87 (m, 2H), 3.64-3.43 (m, 2H), 3.26 (t, J=7.5 Hz, 2H), 2.63 (s, 3H), 1.61-1.18 (m, 9H), 0.74 (t, J=7.2 Hz, 3H); MS (ES+) m/z 326.3 (M+1).

Sources & evidence

ORD record: ord-34e579d800fe465e85e0713288543fc9
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08293768B2

Reaction notes

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