Trifluoroacetic acid → HCID 12207385, compound

HRID 2067715Notes

Reaction equation

HRID 2067715 reaction equation
C(OC([NH:8][CH2:9][C:10]1[O:14][C:13]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:12][CH:11]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][CH2:9][C:10]1[O:14][C:13]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68484335HCID 68484335, compound

Product 1

HCID 12207385HCID 12207385, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a flask, the 5-(tert-butoxycarbonylaminomethyl)furan-2-sulfonamide (5.2 g, 19 mmol) obtained above was added. 200 mL of a mixture of trifluoroacetic acid and dichloromethane (V/V=4:1) was then added to the flask. The reaction mixture was stirred at room temperature for 4 h. After the completion of the reaction, the reaction mixture was then concentrated to give 3.3 g (98.4% yield) of 5-(aminomethyl)furan-2-sulfonamide.

Workup

  1. additionabove was added
  2. customAfter the completion of the reaction
  3. concentrationthe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-f7e0e58c2b174294ab10719df859734e
Source dataset
uspto-grants-2012_10
Patent number
US08293895B2

Reaction notes

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