HRID2067728

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67500672

未命名化合物

结构：C[Si](C)(C)CCOCn1ccnc1CC(COc1ccc(C(=O)O)cc1)Cc1nccn1COCC[Si](C)(C)C

HCID68958419

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCOCn1ccnc1CC(COc1ccc(C(=O)N2CCC3(CCN(C4CCCCC4)CC3)C2)cc1)Cc1nccn1COCC[Si](C)(C)C

HCID68952843

未命名化合物

收率 80.1%

PROCEDURE

实验过程

Except for using the compound (50 mg) produced in Example 103 in place of the compound produced in Example 68 and using 8-cyclohexyl-2,8-diazaspiro[4.5]decane (38 mg) in place of the compound produced in Example 91, the same operation as in Example 92 was performed to obtain the title compound (54 mg) having the following physical properties.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e0dfcae96234891804cb41c116559b1
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08293896B2
来源说明: uspto-grants-2012_10

反应 SMILES

[CH3:1][Si:2]([CH3:40])([CH3:39])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[C:8]1[CH2:12][CH:13]([CH2:25][C:26]1[N:27]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:28]=[CH:29][N:30]=1)[CH2:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1.[CH:41]1([N:47]2[CH2:56][CH2:55][C:50]3([CH2:54][NH:53][CH2:52][CH2:51]3)[CH2:49][CH2:48]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH:41]1([N:47]2[CH2:48][CH2:49][C:50]3([CH2:54][N:53]([C:20](=[O:21])[C:19]4[CH:23]=[CH:24][C:16]([O:15][CH2:14][CH:13]([CH2:12][C:8]5[N:7]([CH2:6][O:5][CH2:4][CH2:3][Si:2]([CH3:1])([CH3:39])[CH3:40])[CH:11]=[CH:10][N:9]=5)[CH2:25][C:26]5[N:27]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:28]=[CH:29][N:30]=5)=[CH:17][CH:18]=4)[CH2:52][CH2:51]3)[CH2:55][CH2:56]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1