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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2067728Generated: October 31, 2026

8-Cyclohexyl-2,8-diazaspiro[4.5]decane → 8-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decane

https://huagongshe.com/reaction/2067728

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Cyclohexyl-2,8-diazaspiro[4.5]decaneHCID 67500672—
Reactant4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoic AcidHCID 68958419—
Product8-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decaneHCID 6895284380.1%

Reaction Steps

Except for using the compound (50 mg) produced in Example 103 in place of the compound produced in Example 68 and using 8-cyclohexyl-2,8-diazaspiro[4.5]decane (38 mg) in place of the compound produced in Example 91, the same operation as in Example 92 was performed to obtain the title compound (54 mg) having the following physical properties.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08293896B2
Source datasetuspto-grants-2012_10
ORD IDord-8e0dfcae96234891804cb41c116559b1
Source noteuspto-grants-2012_10