Phosphorus oxychloride → HCID 59823064, compound

HRID 2067746Notes

Reaction equation

HRID 2067746 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[C:15](O)=[C:16]([CH3:21])[C:17](=[O:20])[N:18]([CH3:19])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:25]>>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[C:15]([Cl:25])=[C:16]([CH3:21])[C:17](=[O:20])[N:18]([CH3:19])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 598230503-Benzyl-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Product 1

HCID 59823064HCID 59823064, compound

Procedure

3-Benzyl-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (5.5 g, 18.5 mmol) was dissolved in excess POCl3 (50 mL) and heated at reflux for 1 hour. POCl3 was removed in vacuo and the residue dissolved in DCM then quickly washed with saturated sodium bicarbonate solution until neutral pH was observed. The organic layer was dried over MgSO4 and evaporated to dryness to give 7.3 g of the title compound as an impure reddish brown solid. [M+H] calc'd for C16H14ClN3O2, 315; found, 315.

Workup

  1. temperatureheated
  2. temperatureat reflux for 1 hour
  3. customPOCl3 was removed in vacuo
  4. dissolutionthe residue dissolved in DCM
  5. washthen quickly washed with saturated sodium bicarbonate solution until neutral pH
  6. dry with materialThe organic layer was dried over MgSO4
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-097d6a52fe2d447d8cb8f7d347d824f7
Source dataset
uspto-grants-2012_10
Patent number
US08293901B2

Reaction notes

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