HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethyldimethylammonium bromide → 3-(2-(Dimethylamino)ethyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethyldimethylammonium bromide | HCID 45791347 | — |
| Reactant | (S)-3-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 59823036 | — |
| Reactant | 5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 135741654 | — |
| Product | 3-(2-(Dimethylamino)ethyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 24967884 | — |
Reaction Steps
The title compound was prepared following the same procedure for the synthesis of compound 5G using compound 5F and 2-bromo-N,N-dimethylethanamine hydrobromide as starting material. 1H NMR (400 MHz, MeOD) δ 8.57 (s, 1 H) 7.68 (m, 2H) 7.33 (t, J=8.36 Hz, 1 H) 5.78 (s, 1 H) 4.51 (t, J=4.0 Hz, 2 H) 3.69 (s, 3 H) 3.66 (t, J=8.0 Hz, 2 H) 3.09 (s, 6 H). [M+H] calc'd for C18H19FIN5O2, 484; found, 484.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293901B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-cb5a5d15a844403982eec09c04941b6e |
| Source note | uspto-grants-2012_10 |