Acetic Acid → 2-(Trifluoromethyl)piperazine

HRID 2067886Notes

Reaction equation

HRID 2067886 reaction equation
C([N:8]1[CH2:13][CH2:12][NH:11][CH:10]([C:14]([F:17])([F:16])[F:15])[CH2:9]1)C1C=CC=CC=1.CC(O)=O.[H][H]>CO.[Pd]>[F:15][C:14]([F:17])([F:16])[CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][NH:11]1

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 534071701-Benzyl-3-(trifluoromethyl)piperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 185197252-(Trifluoromethyl)piperazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-Benzyl-3-(trifluoromethyl)piperazine 34a (4.1 mmol) is dissolved in MeOH (50 mL) followed by addition of AcOH (2.0 mL) and 5% mol of Pd/C. The flask is charged with a hydrogen balloon and stirred for 12 h. The mixture is filtered over celite and the filtrate is concentrated to afford 2-(trifluoromethyl)piperazine 35a, which is used without further purification. MS (m/z) (M+1)+: 155.1.

Workup

  1. filtrationThe mixture is filtered over celite
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-f4879ccdb1af424b8a6eb3850d31706d
Source dataset
uspto-grants-2012_10
Patent number
US08293757B2

Reaction notes

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