HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-(Trifluoromethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1-Benzyl-3-(trifluoromethyl)piperazine | HCID 53407170 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Trifluoromethyl)piperazine | HCID 18519725 | — |
Reaction Steps
1-Benzyl-3-(trifluoromethyl)piperazine 34a (4.1 mmol) is dissolved in MeOH (50 mL) followed by addition of AcOH (2.0 mL) and 5% mol of Pd/C. The flask is charged with a hydrogen balloon and stirred for 12 h. The mixture is filtered over celite and the filtrate is concentrated to afford 2-(trifluoromethyl)piperazine 35a, which is used without further purification. MS (m/z) (M+1)+: 155.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293757B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-f4879ccdb1af424b8a6eb3850d31706d |
| Source note | uspto-grants-2012_10 |