Hydrochloric Acid → HCID 67393462, compound

Participants

Reaction Steps

(S,S)-2-Methyl-propane-2-sulfinic acid 1-(6-trifluoromethyl-pyridin-2-yl)-butylamide (290 mg, 0.92 mmol) is treated with HCl in dioxane (4.0 N solution, 10 mL, 40 mmol) at room temperature and stirred for 30 min. The reaction mixture is concentrated in vacuo to afford (S)-1-(6-trifluoromethyl-pyridin-2-yl)-butylamine hydrochloride (200 mg, 88%) which is used without further purification [note: the enantiomeric purity (% ee) has not been determined].

Provenance & Evidence