Hydrochloric Acid → HCID 67393462, compound

HRID 2067955Notes

Reaction equation

HRID 2067955 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[N:8]=[C:7]([C@@H:9]([NH:13][S@](C(C)(C)C)=O)[CH2:10][CH2:11][CH3:12])[CH:6]=[CH:5][CH:4]=1.[ClH:22].O1CCOCC1>>[ClH:22].[F:20][C:2]([F:1])([F:21])[C:3]1[N:8]=[C:7]([C@@H:9]([NH2:13])[CH2:10][CH2:11][CH3:12])[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58443408HCID 58443408, compound

Product 1

HCID 67393462HCID 67393462, compoundYield 88%

Procedure

(S,S)-2-Methyl-propane-2-sulfinic acid 1-(6-trifluoromethyl-pyridin-2-yl)-butylamide (290 mg, 0.92 mmol) is treated with HCl in dioxane (4.0 N solution, 10 mL, 40 mmol) at room temperature and stirred for 30 min. The reaction mixture is concentrated in vacuo to afford (S)-1-(6-trifluoromethyl-pyridin-2-yl)-butylamine hydrochloride (200 mg, 88%) which is used without further purification [note: the enantiomeric purity (% ee) has not been determined].

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-75e9da1c5e4f45618be2dfdd9ed26c79
Source dataset
uspto-grants-2012_10
Patent number
US08293917B2

Reaction notes

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