反应详情

2-Methyl-propane-2-sulfinic acid 1-(5-bromo-pyridin-3-yl)-butylamide (16 g, 48 mmol) is treated with aqueous HCl (3.0 N solution, 400 mL, 1.2 mol) at room temperature and stirred for 5 hours. The reaction mixture is quenched by addition of saturated aqueous sodium carbonate solution until pH 8 and extracted with dichloromethane (3×300 mL). The combined organic phases are dried over Na2SO4, filtered, and concentrated to afford 1-(5-bromo-pyridin-3-yl)-butylamine (9.5 g, 86%) of as a light brown oil.

1. customThe reaction mixture is quenched by addition of saturated aqueous sodium carbonate solution until pH 8
2. extractionextracted with dichloromethane (3×300 mL)
3. dry with materialThe combined organic phases are dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated