HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → HCID 6457808, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 6457808 | HCID 6457808 | — |
Reaction Steps
A 2-amino-thiazole derivative is condensed with a benzylisocyanate by heating with a basic catalyst (typically DMAP) in an inert organic solvent (typically THF or NMP) to afford the corresponding 1-(thiazol-2-yl)-3-benzyl-urea, which is purified by silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293919B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-280f6544deaa4541bf82342c32b99d69 |
| Source note | uspto-grants-2012_10 |