2-Aminothiazole → HCID 6457808, compound

HRID 2068005Notes

Reaction equation

HRID 2068005 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH2:7]([N:14]=[C:15]=[O:16])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C1COCC1>CN(C1C=CN=CC=1)C.CN1C(=O)CCC1>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[NH:1][C:15]([NH:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:16]

Participants

6

Reactant 3

HCID 21552-AminothiazoleHCID 8028TetrahydrofuranHCID 76639Benzyl isocyanate

Product 1

HCID 6457808HCID 6457808, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A 2-amino-thiazole derivative is condensed with a benzylisocyanate by heating with a basic catalyst (typically DMAP) in an inert organic solvent (typically THF or NMP) to afford the corresponding 1-(thiazol-2-yl)-3-benzyl-urea, which is purified by silica gel chromatography.

Sources & evidence

ORD record
ord-280f6544deaa4541bf82342c32b99d69
Source dataset
uspto-grants-2012_10
Patent number
US08293919B2

Reaction notes

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