HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(Methylsulfonyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate | HCID 4496004 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Methylsulfonyl)piperazine | HCID 709161 | 50.1% |
Reaction Steps
A solution of tert-butyl 4-(methylsulphonyl)piperazine-1-carboxylate (7 g) in methylene chloride (150 ml) containing TFA (35 ml) was stirred for 2 hours at ambient temperature. The volatiles were removed under vacuum and the resultant residue was partitioned between methylene chloride and 2N aqueous sodium hydroxide. The organic phase was separated and washed with brine, dried over magnesium sulphate and evaporated to give 1-(methylsulphonyl)piperazine (2.18 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293902B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-71b29db507144912afd4152fc1abbdc1 |
| Source note | uspto-grants-2012_10 |