反应详情

温度

70 °C

A suspension of 1-(methylsulphonyl)piperazine (3 g, 18.3 mmol), 3-bromopropan-1-ol (3.3 g, 23.8 mmol) and potassium carbonate (3.28 g, 23.8 mmol) in acetonitrile (20 ml) was stirred at 70° C. for 4 hours. After cooling, the mixture was filtered and the filtrate was evaporated. The residue was purified by column chromatography eluting with increasingly polar mixtures of methanol and methylene chloride to give 3-(4-methylsulphonylpiperazin-1-yl)propan-1-ol (2.93 g, 72%).

1. temperatureAfter cooling
2. filtrationthe mixture was filtered
3. customthe filtrate was evaporated
4. customThe residue was purified by column chromatography
5. washeluting
6. temperaturewith increasingly polar mixtures of methanol and methylene chloride