HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ertapenem disodium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, monosodium salt, (4R,5S,6S)- | HCID 66598136 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | Ertapenem disodium | HCID 150611 | — |
Reaction Steps
To the solution of sodium bicarbonate (2.5 g in 70 mL water) Ertapenem monosodium (15 g) was slowly added at 0-5° C., by maintaining pH around 7.5 using sodium hydroxide solution. The solution obtained was subjected to carbon treatment, followed by stirred with alumina and filtered. To filtrate, containing Ertapenem disodium was filtered through 0.2 micron filter paper and added into 2500 mL of cold IPA solution at 0-5° C. The solid obtained was filtered washed with IPA followed by acetone and IPE, dried under dry and wet nitrogen to yield Ertapenem disodium (Yield—8-12 g; sodium content: 9.2-10.5%; moisture content: 5-7%; pH: 7.5-8.0). The color of the reconstituted product was pale yellow.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293924B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-25eb0003c4a14a91b78c164bc984c6a8 |
| Source note | uspto-grants-2012_10 |