反应详情

To the solution of sodium bicarbonate (2.5 g in 70 mL water) Ertapenem monosodium (15 g) was slowly added at 0-5° C., by maintaining pH around 7.5 using sodium hydroxide solution. The solution obtained was subjected to carbon treatment, followed by stirred with alumina and filtered. To filtrate, containing Ertapenem disodium was filtered through 0.2 micron filter paper and added into 2500 mL of cold IPA solution at 0-5° C. The solid obtained was filtered washed with IPA followed by acetone and IPE, dried under dry and wet nitrogen to yield Ertapenem disodium (Yield—8-12 g; sodium content: 9.2-10.5%; moisture content: 5-7%; pH: 7.5-8.0). The color of the reconstituted product was pale yellow.

1. temperatureby maintaining pH around 7.5
2. customThe solution obtained
3. filtrationfiltered
4. additionTo filtrate, containing Ertapenem disodium
5. filtrationwas filtered through 0.2 micron
6. filtrationfilter paper
7. additionadded into 2500 mL of cold IPA solution at 0-5° C
8. customThe solid obtained
9. filtrationwas filtered
10. washwashed with IPA
11. customdried
12. customunder dry