HRID2068140

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19691292

tert-Butyl octahydro-5H-pyrrolo[3,4-c]pyridine-5-carboxylate

C12H22N2O2

结构：O=S(=O)(c1cccc(OC(F)(F)F)c1)c1cnc2c(I)cccc2c1

HCID68729086

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC2CN(c3cccc4cc(S(=O)(=O)c5cccc(OC(F)(F)F)c5)cnc34)CC2C1

HCID25196511

未命名化合物

收率 54%

PROCEDURE

实验过程

The title compound was prepared by analogy to the procedure of Example 1.3, except using tert-butyl hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate and 8-iodo-3-(3-(trifluoromethoxy)phenylsulfonyl)quinoline. 130 mg (54%) of the title compound were obtained as a pale yellow solid.

WORKUP

后处理

customThe title compound was prepared by analogy to the procedure of Example 1.3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-33f59e59cc0c4fcd9053a40576db069e
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08293913B2

反应 SMILES

[CH2:1]1[CH:9]2[CH:4]([CH2:5][N:6]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7][CH2:8]2)[CH2:3][NH:2]1.I[C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[N:26]=[CH:25][C:24]([S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([O:37][C:38]([F:41])([F:40])[F:39])[CH:32]=1)(=[O:30])=[O:29])=[CH:23]2>>[F:41][C:38]([F:39])([F:40])[O:37][C:33]1[CH:32]=[C:31]([S:28]([C:24]2[CH:25]=[N:26][C:27]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][C:18]=3[N:2]2[CH2:1][CH:9]3[CH:4]([CH2:5][N:6]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7][CH2:8]3)[CH2:3]2)(=[O:29])=[O:30])[CH:36]=[CH:35][CH:34]=1