HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1S,5S)-3-(3-(3-fluorophenylsulfonyl)quinolin-8-yl)-3-aza-6-azoniabicyclo[3.2.0]heptane hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (1R,5S)-3,6-diazabicyclo[3.2.0]heptane-6-carboxylate | HCID 23635158 | — |
| Reactant | 3-(3-Fluorophenylsulfonyl)-8-iodoquinoline | HCID 67314157 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (1S,5S)-3-(3-(3-fluorophenylsulfonyl)quinolin-8-yl)-3-aza-6-azoniabicyclo[3.2.0]heptane hydrochloride | HCID 86647687 | — |
Reaction Steps
0.081 g of (1S,5S)-3-(3-(3-fluorophenylsulfonyl)quinolin-8-yl)-3-aza-6-azoniabicyclo[3.2.0]heptane hydrochloride were prepared by analogy to the methods of Examples 27 and 28 by coupling of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline with (1R,5S)-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate and subsequent deprotection of the tert-butyl-oxycarbonyl derivative with HCl in isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293913B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9a57282d8e9041288b4113d0147c903b |
| Source note | uspto-grants-2012_10 |