Dichloromethane → Dimethyl 2-(2-fluorobenzyl)piperidine-1,4-dicarboxylate

HRID 206823Notes

Reaction equation

HRID 206823 reaction equation
[CH:19]([N:20]([CH2:21][CH3:22])[CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[Cl:28][C:29](=[O:30])[O:31][CH3:32].[Cl:33][CH2:34][Cl:35].[F:1][c:2]1[c:3]([CH2:4][CH:5]2[NH:6][CH2:7][CH2:8][CH:9]([C:11](=[O:12])[O:13][CH3:14])[CH2:10]2)[cH:15][cH:16][cH:17][cH:18]1>>[F:1][c:2]1[c:3]([CH2:4][CH:5]2[N:6]([C:29](=[O:30])[O:31][CH3:32])[CH2:7][CH2:8][CH:9]([C:11](=[O:12])[O:13][CH3:14])[CH2:10]2)[cH:15][cH:16][cH:17][cH:18]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6586Methyl chloroformateHCID 81531DiisopropylethylamineHCID 66732347Methyl 2-(2-fluorobenzyl)piperidine-4-carboxylate

Product 1

HCID 66734736Dimethyl 2-(2-fluorobenzyl)piperidine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-41ea16dc82d747c3a27197232aa12302
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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