Hydrochloric Acid → N4-{4-[(3-Cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3,5-difluorophenyl}-6-(trifluoromethyl)-pyrimidine-2,4-diamine
Reaction equation
[CH3:39][CH2:40][OH:41].[CH:1]1([c:4]2[cH:5][nH:6][c:7]3[n:8][cH:9][cH:10][c:11]([O:13][c:14]4[c:15]([F:22])[cH:16][c:17]([NH2:18])[cH:19][c:20]4[F:21])[c:12]23)[CH2:2][CH2:3]1.[Cl:23][c:24]1[n:25][c:26]([NH2:34])[n:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]1.[ClH:35].[Na+:37].[OH-:36].[OH2:38]>>[CH:1]1([c:4]2[cH:5][nH:6][c:7]3[n:8][cH:9][cH:10][c:11]([O:13][c:14]4[c:15]([F:22])[cH:16][c:17]([NH:18][c:24]5[n:25][c:26]([NH2:34])[n:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]5)[cH:19][c:20]4[F:21])[c:12]23)[CH2:2][CH2:3]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-19b270a4e22745bdba116526e6888c0d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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