反应详情

In a 20 mL vial with septum cover was added {1-cyclohexyl-2-[5-(3-methoxymethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-3-ylamino]-1H-benzoimidazol-5-yl}-methanol (58 mg, 0.000095 mol), ethanol (6.0 mL) and HCl (2.0 mL, 0.065 M). The mixture was refluxed for 1.5 hr. The mixture was concentrated and the residue dissolved in approx 1.5 mL of DMSO and purified by HPLC. The product fractions were lyopholized overnight to give 11.9 mg of the title compound as an off white solid.

1. temperatureThe mixture was refluxed for 1.5 hr
2. concentrationThe mixture was concentrated
3. dissolutionthe residue dissolved in approx 1.5 mL of DMSO
4. custompurified by HPLC