Sodium Hydroxide → HCID 178518705, compound

HRID 2068575Notes

Reaction equation

HRID 2068575 reaction equation
[OH-:1].[Na+].Cl[C:4]1[NH:5][C:6]([Cl:13])=[CH:7][C:8]2[C:9]=1[NH:10][CH2:11][N:12]=2>O>[Cl:13][C:6]1[NH:5][C:4](=[O:1])[C:9]2[NH:10][CH:11]=[N:12][C:8]=2[CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178477824HCID 178477824, compound

Product 1

HCID 178518705HCID 178518705, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
90 °C

Procedure

An aqueous NaOH solution (2 equiv.) was added to a solution of 4,6-dichloro-3,5-dihydro-imidazo[4,5-c]pyridine in water. The reaction mixture was stirred at 90° C. until the completion of the reaction (monitored by TLC). The reaction mixture was allowed to cool down to room temperature and filtered to give light yellow residue. The residue was dissolved in water and acidified to pH 3-4 and was filtered to give 2.

Workup

  1. temperatureto cool down to room temperature
  2. filtrationfiltered
  3. customto give light yellow residue
  4. filtrationwas filtered
  5. customto give 2

Sources & evidence

ORD record
ord-b7b2cf547ead405282b1cd2534c962cb
Source dataset
uspto-grants-2012_10
Patent number
US08299023B2

Reaction notes

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