HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67212144, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 67212124 | HCID 67212124 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 67212144 | HCID 67212144 | — |
Reaction Steps
Aqueous 1N LiOH (5 equiv.) was added to a solution of 4-(3-ethoxycarbonylmethyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-6-yl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester, 6 dissolved in tetrahydrofuran/water (7:1) at room temperature Then the mixture was stirred at room temperature for 10 min. The solution was acidified (pH=3˜4) with 1 N HCl. Tetrahydrofuran was then added. Purification by silica gel chromatography gave 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299023B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b8e51d2fb8a44de180ac5c32e7f77a69 |
| Source note | uspto-grants-2012_10 |