Hydrochloric Acid → HCID 67212144, compound

HRID 2068578Notes

Reaction equation

HRID 2068578 reaction equation
[Li+].[OH-].[CH:3]1[C:15]2[CH:14]([CH2:16][O:17][C:18]([N:20]3[CH2:25][CH2:24][N:23]([C:26]4[NH:31][C:30](=[O:32])[C:29]5[N:33]([CH2:36][C:37]([O:39]CC)=[O:38])[CH:34]=[N:35][C:28]=5[CH:27]=4)[CH2:22][CH2:21]3)=[O:19])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl.O1CCCC1>O1CCCC1.O>[CH:12]1[C:13]2[CH:14]([CH2:16][O:17][C:18]([N:20]3[CH2:25][CH2:24][N:23]([C:26]4[NH:31][C:30](=[O:32])[C:29]5[N:33]([CH2:36][C:37]([OH:39])=[O:38])[CH:34]=[N:35][C:28]=5[CH:27]=4)[CH2:22][CH2:21]3)=[O:19])[C:15]3[C:7](=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:8]=2[CH:9]=[CH:10][CH:11]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 67212124HCID 67212124, compound

Product 1

HCID 67212144HCID 67212144, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

Aqueous 1N LiOH (5 equiv.) was added to a solution of 4-(3-ethoxycarbonylmethyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-6-yl)-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester, 6 dissolved in tetrahydrofuran/water (7:1) at room temperature Then the mixture was stirred at room temperature for 10 min. The solution was acidified (pH=3˜4) with 1 N HCl. Tetrahydrofuran was then added. Purification by silica gel chromatography gave 7.

Workup

  1. customPurification by silica gel chromatography
  2. customgave 7

Sources & evidence

ORD record
ord-b8e51d2fb8a44de180ac5c32e7f77a69
Source dataset
uspto-grants-2012_10
Patent number
US08299023B2

Reaction notes

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