Sodium Hydroxide → 2-Chlorohypoxanthine
Reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[OH-:12].[Na+]>O>[Cl:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[NH:6][CH:7]=[N:8][C:9]=2[N:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of compound 2,6-dichloro-7H-purine, 1 (60 g, 300 mL) and NaOH (30 g) in water was stirred at 100° C. for 5 h, then the reaction mixture was cooled to room temperature and was filtered. The solid was washed with ethyl acetate, then dissolved in water, treated with aq. HCl solution until pH was adjusted to 4. A precipitate formed overnight, the solid was filtered, was washed with a little water, and was dried to give 2.
Workup
- temperaturethe reaction mixture was cooled to room temperature
- filtrationwas filtered
- washThe solid was washed with ethyl acetate
- dissolutiondissolved in water
- additiontreated with aq. HCl solution until pH
- customA precipitate formed overnight
- filtrationthe solid was filtered
- washwas washed with a little water
- customwas dried
- customto give 2
Sources & evidence
- ORD record
- ord-5a5a87a4a7994474838ac72f5bf26885
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08299023B2
Reaction notes
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