Sodium Hydroxide → 2-Chlorohypoxanthine

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 2,6-dichloro-7H-purine, 1 (60 g, 300 mL) and NaOH (30 g) in water was stirred at 100° C. for 5 h, then the reaction mixture was cooled to room temperature and was filtered. The solid was washed with ethyl acetate, then dissolved in water, treated with aq. HCl solution until pH was adjusted to 4. A precipitate formed overnight, the solid was filtered, was washed with a little water, and was dried to give 2.

Provenance & Evidence