反应详情

A solution of compound 6 (6.8 g, 25.4 mmol), tert-butyl piperazine-1-carboxylate (5.68 g, 30.5 mmol), Pd2(dba)3 (775 mg, 0.85 mmol), S-Phos (1.16 g) and t-BuOK (5.7 g, 50.8 mmol) in toluene (100 mL) was heated to 90° C. under nitrogen overnight. Then the mixture was cooled to room temperature and filtered. The filtrate was concentrated, the residue was dissolved in methylene chloride, washed with water, dried (sodium sulfate), concentrated and purified by flash column chromatography (silica gel) to give 7 (6.1 g, 64%)

1. filtrationfiltered
2. concentrationThe filtrate was concentrated
3. dissolutionthe residue was dissolved in methylene chloride
4. washwashed with water
5. dry with materialdried (sodium sulfate)
6. concentrationconcentrated
7. custompurified by flash column chromatography (silica gel)