Sodium Hydroxide → 5-Oxazol-4-yl-thiophene-3-carboxylic acid

HRID 2068635노트

반응식

C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>>[O:13]1[CH:14]=[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[N:11]=[CH:12]1

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 581102445-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester

생성물 1

HCID 581102215-Oxazol-4-yl-thiophene-3-carboxylic acid수율 100.2%

실험 절차

5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester (0.049 g, 0.23 mmol) was suspended in IMS (1 mL), sodium hydroxide (1 M, 0.35 mL) was added and the mixture stirred for 60 hours at room temperature. The mixture was quenched with HCl (1 N, 0.35 mL) and then concentrated, azeotroping twice with methanol to afford 5-oxazol-4-yl-thiophene-3-carboxylic acid as a white solid (0.045 g).

후처리

customThe mixture was quenched with HCl (1 N, 0.35 mL)
concentrationconcentrated
customazeotroping twice with methanol

출처 및 근거

ORD 기록: ord-a9e15b923af248999376c9b186edc511
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08299063B2

반응 노트

불러오는 중…