反应详情

5-(2-Fluoro-pyridin-4-yl)-thiophene-3-carboxylic acid (0.05 g, 0.22 mmol) was dissolved in acetonitrile (2 mL) together with cis, trans-decahydroisoquinoline (0.134 mL, 0.90 mmol), triethylamine (80 μL, 0.60 mmol) and HATU (0.085 g, 0.22 mmol) and the resulting mixture was stirred over the weekend. The crude material was purified by HPLC, eluting with 10%-98% acetonitrile in water (0.1% formic acid). The fractions containing the desired product were evaporated to give the title compound as an oil (0.02 g). LCMS m/z 345.22 [M+H]+ R.T.=11.64 min (Analytical Method 2).

1. customThe crude material was purified by HPLC
2. washeluting with 10%-98% acetonitrile in water (0.1% formic acid)
3. additionThe fractions containing the desired product
4. customwere evaporated