反应详情

温度

70 °C

To a solution of 1-benzoyl-3-(5-bromo-2,4-difluoro-phenyl)-thiourea II (1.70 g, 4.60 mmol) in THF (35.0 mL) was added a solution of NaOH (0.97 g, 24.25 mmol) in water (13.0 mL). The resulting reaction mixture was stirred at 70° C. for 15 h. After the completion of the reaction (TLC monitoring), THF was evaporated, added water and extracted with EtOAc (3×50 mL). The combined organics was washed with brine and concentrated to obtain the desired compound (1.0 g, 83%). MS: 267.03 (M+H)+.

1. customThe resulting reaction mixture
2. customwas evaporated
3. additionadded water
4. extractionextracted with EtOAc (3×50 mL)
5. washThe combined organics was washed with brine
6. concentrationconcentrated