反应详情

温度

65 °C

Under a nitrogen atmosphere, to a solution of benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate obtained in Example 3 (7.2 g, 17 mmol) in ethanol (72 ml) were added 10% palladium-carbon (723 mg) and ammonium formate (2.5 g, 39 mmol), and the mixture was stirred with heating at 65° C. for 40 min. After cooling, the reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was slurry-washed in water (300 ml). The precipitate was collected by filtration, washed with water, and dried under reduced pressure to give the title compound (4.5 g, yield 90%).

1. temperatureAfter cooling
2. filtrationthe reaction mixture was filtered through celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. washThe residue was slurry-washed in water (300 ml)
5. filtrationThe precipitate was collected by filtration
6. washwashed with water
7. customdried under reduced pressure