反应详情

To a solution of (S)—N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl]-N-methyl-2-(morpholin-4-yl)propionamide obtained in Example 4 (100 mg, 0.23 mmol) in ethyl acetate (1 ml) was added 4 N hydrochloric acid/ethyl acetate (0.06 ml, 0.24 mmol) at room temperature, and the mixture was stirred for 30 min. The precipitated crystals were collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (75 mg, 69%).

1. filtrationThe precipitated crystals were collected by filtration
2. washwashed with ethyl acetate
3. customdried under reduced pressure