反应详情

A mixture of 1-(4-chloro-2-nitrophenyl)-2-isopropyl-1H-imidazole as synthesized in above Production Example 7, 0.98 g, tin (II) chloride dihydrate 4.16 g and ethanol 8.8 mL was heated under reflux for 2.7 hours. Neutralizing the reaction liquid with 2N aqueous sodium hydroxide solution under cooling with ice, chloroform was added to the reaction liquid and filtered through Celite. The Celite was washed with chloroform, transferred into a separating funnel and extracted twice with chloroform. The organic layer was washed with water, dried over magnesium sulfate and removed of the solvent by distillation, to provide 0.72 g of the title compound.

1. temperaturewas heated
2. temperatureunder reflux for 2.7 hours
3. additionwas added to the reaction liquid
4. filtrationfiltered through Celite
5. washThe Celite was washed with chloroform
6. customtransferred into a separating funnel
7. extractionextracted twice with chloroform
8. washThe organic layer was washed with water
9. dry with materialdried over magnesium sulfate
10. customremoved of the solvent by distillation