HCID 58532561, compound → HCID 58532571, compound

HRID 2069054Notes

Reaction equation

HRID 2069054 reaction equation
[N+:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([O:14][CH:15]([CH3:31])[CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])[CH:18]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[Pt]>[NH2:1][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([O:14][CH:15]([CH3:31])[CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:28])([CH3:27])[CH3:29])[CH:18]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 58532561HCID 58532561, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58532571HCID 58532571, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A solution of tert-butyl 4-(2-(4-nitronaphthalen-1-yloxy)propyl)pyridin-2-ylcarbamate (48) (271 mg, 0.614 mmol) in MeOH (30 mL) was passed through a Thales H-cube (1.0 mL·min−1, 30° C., 55 mm, 10% Pt/C Cat-Cart, full hydrogen mode) and the volatiles were removed in vacuo to afford the title compound (49) (241 mg, 100%) as a purple foam: m/z 394.0 (M+H)+ (ES+).

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-d8ad8f18299540dead366251a61c238f
Source dataset
uspto-grants-2012_10
Patent number
US08299073B2

Reaction notes

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