反应详情

To a stirred solution of the tert-butyl carbamate (50) (158 mg, 0.244 mmol) in DCM (4 mL) at 0° C. under nitrogen was added TFA (2 mL). After 5 min the reaction mixture was warmed to RT and stirred for a further 2 hr. The mixture was evaporated in vacuo and the residue was subjected to SCX capture and release to afford the title compound (Intermediate J) (138 mg, >100%): m/z 549 (M+H)+ (ES+).

1. customThe mixture was evaporated in vacuo