反应详情

温度

140 °C

Sodium sulfate (2.8 g) and manganese dioxide (7.1 g; Ald) were added to a toluene (60 mL) solution of Intermediate 5 (1.99 g) and the resulting mixture was stirred at 140° C. for 24 hours. The reaction mixture was filtrated through celite followed by the addition of 2 N hydrochloric acid and the resulting mixture was washed with ether. The resulting mixture was neutralized with 5 N aqueous sodium hydroxide solution and then extracted with dichloromethane to give the title compound (698 mg).

1. filtrationThe reaction mixture was filtrated through celite
2. additionfollowed by the addition of 2 N hydrochloric acid
3. washthe resulting mixture was washed with ether
4. extractionextracted with dichloromethane